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The in vitro investigation of composite hydrogel scaffolds indicated that their controllable architectures enabled significant stimulation of both 3T3-L1 preadipocytes and human umbilical vein endothelial cells across cell behaviors such as adhesion, proliferation, migration, and differentiation. The composite scaffold, in conjunction with a live animal model, enhanced the restoration of vascularized adipose tissue beneath the skin of nude mice. These 3D-printed GelMA