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The intricate O-linked protein glycosylation system of these bacteria requires further research to elucidate the correlation between pgl gene variations and the creation of a high degree of glycoform diversity, while also understanding immune evasion. A pathogenic role for autoreactive CD8+ T cells has been established in vitiligo, specifically in mediating the destruction of epidermal melanocytes. MIF, a multifaceted molecule crucial for immune processes, such as the activation and proliferation of T cel