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Epidemiological studies, prognostic in nature; Level V. Epidemiological and prognostic analyses; Level V. Acetamiprid (ACP) exposure leads to infertility, and oxidative stress appears to play a pivotal role in this effect. Melatonin's effectiveness as an antioxidant is a recognized characteristic. This experimental research investigated the protective mechanisms of melatonin against ACP-induced pathological alterations in the reproductive parameters of female mice. Fifty