https://akt-signal.com/index.p....hp/longitudinal-decl
We announce the development of UNC7700, a potent degrader of PRC2, with a focus on EED. In diffuse large B-cell lymphoma DB cells, UNC7700, containing a unique cis-cyclobutane linker, demonstrated potent degradation of PRC2 components. Specifically, EED (DC50 = 111 nM; Dmax = 84%), EZH2WT/EZH2Y641N (DC50 = 275 nM; Dmax = 86%), and to a lesser degree SUZ12 (Dmax = 44%) were degraded after 24 hours. The characterization of UNC7700 and similar compounds, with regard to their ternary complex formation