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th breast cancer are warranted. [HLRP Health Literacy Research and Practice. 2021;5(3)e171-e178.] Plain Language Summary In this study, the majority of patients with breast cancer were found to have high levels of cancer health literacy, patient activation, and health-related quality of life (HRQoL). The significant relationship between patient activation and HRQoL implies that patients with breast cancer who are able to actively participate in managing their health and health care are more likely to have higher HRQoL. Interventions th