https://www.selleckchem.com/pr....oducts/filanesib.htm
The two main pathological hallmarks of Parkinson's disease are loss of dopamine neurons in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of α-synuclein, called Lewy pathology. Levodopa to enhance dopaminergic transmission remains one of the most effective treatment for alleviating the motor symptoms of Parkinson's disease (Olanow, Mov Disord 34812-815, 2019). In addition, deep brain stimulation (Bronstein et al., Arch Neurol 68165, 2011) to modulate basal ganglia circuit activity successfully all