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Interestingly, the p110α, p110δ, and the general PI3K inhibitor do not improve arterial healing after injury in hypercholesterolemic female mice. These results indicate a potential new role for isoform-specific PI3K inhibitors in male patients following arterial injury/intervention. The results also identify significant **** differences in the response to PI3K inhibition in the cardiovascular system, where female **** generally has a cardioprotective effect. This study provides a foundation to investigate the mechanism for the **** differen
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