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ekly mean of the 24-hour average pain score, using a numeric rating scale (NRS), from baseline to Week 12. Both the studies were prematurely terminated due to preclinical hepatotoxicity on long-term dosing, although not observed in these studies. Out of the planned participants, a total of 129/360 (EMPHENE) and 137/400 (EMPADINE) participants were enrolled. The least square mean reduction in NRS pain score was numerically in favour of EMA401 100 mg arm in both EMPHENE (TD -0.5 [95%CI -1.6, 0.6; p value 0.35]) and EMPADINE (treatment di