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Differences of genotypes between male and female have been studied in Parkinson's disease (PD), but limited research has focused on the comparison between ****es with LRRK2 G2385 variant. The aim of this study was to explore **** effects in the same genetic subtype and role of leucine-rich repeat kinase 2 (LRRK2) G2385R variants in the same **** in PD. 613 PD patients were recruited from the Movement Disorders Clinic in Ruijin Hospital. We did not include healthy controls in this study. The data collected includes demographic information,