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Experiments on 2900 left ventricle segments of 145 subjects from short-axis magnetic resonance imaging sequences of multiple lengths prove that our proposed method achieves reliable performance (correlation coefficient 0.946; mean absolute error 2.67; standard deviation 3.23). As compared with the current state-of-the-art method, our proposed method improves the performance by approximately 3% insofar as the mean absolute error. As the first solution for estimating the left ventricular ejection fraction directly, our proposed method de