https://www.selleckchem.com/pr....oducts/gsk591-epz015
T2DM db/db coronary VSMCs generated enhanced traction force by TFM (Control 692±67 Pa vs db/db 1507±207 Pa; p less then 0.01). Immunoblot analysis showed that T2DM human coronary VSMC expressed reduced β1 integrin and elevated β3 integrin (Control 1.00 ± 0.06 vs. T2DM 0.62 ± 0.14, p less then 0.05 and Control 1.00 ± 0.49 vs. T2DM 3.39 ± 1.05, p=0.06, respectively). These data show that T2DM coronary VSMCs are less stiff and less adhesive to fibronectin but are able to generate enhanced force, corroborating previously
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