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NH4+-N was mainly oxidized to N2. Economic evalution revealed that the treatment cost was 2.93 $/m3.Antibiotics, antimicrobial resistance determinants and human pathogens are new types of environmental pollutants that pose a great threat to human health. Wastewater treatment plants (WWTPs) are important sources of novel pollutants; however, few studies have investigated their impact on surrounding natural water. Therefore, this study used a WWTP as the entry point to explore WWTP removal efficiency of antibiotics, antimicrobial resistance