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Crosstalk through receptor ligand interactions at the maternal-fetal interface is impacted by fetal ****. This affects placentation in the first trimester and differences in outcomes. Sexually dimorphic signaling at early stages of placentation are not defined. Investigate the impact of fetal **** on maternal-fetal crosstalk. Receptors/ligands at the maternal-fetal surface were identified from ****ually dimorphic genes between fetal ****es in the first trimester placenta and defined in each cell type using single-cell RNA-Sequencing (scRNA-Se