https://hdacassay.com/treatmen....ts-for-a-new-parkins
Vps34's lactylation significantly improves its affinity for Beclin1, Atg14L, and UVRAG, resulting in a corresponding augmentation of Vps34's lipid kinase activity. VPS34 lactylation contributes to both autophagic flux and the regulation of endolysosomal trafficking. Intense exercise-induced VPS34 lactylation in skeletal muscle maintains cellular homeostasis within muscle cells, a process that is also linked to cancer development through its induction of autophagy. The au
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