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Among the upregulated DEGs in CAS patients, FABP4 exhibited the highest | log (fold change)|. Furthermore, FABP4 was positively associated with and had the highest Spearman's correlation coefficient and the most significant -value among the microbiota-DEG pairs. In this study, we investigated the potential "microbiota-metabolite-gene" regulatory axis that may act on CAS, and our results may help to establish a theoretical basis for further specialized study of this disease. In this study, we investigated the potential "microbiota-metabol