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s of different diagnostic criteria for objective cognitive impairment, for use in both clinical and research settings on MCI and dementia. Muscle biopsy is still an important exam on the investigation of neuromuscular diseases although data regarding its diagnostic yield can be disappointing. We aimed to analyze the diagnostic yield of muscle biopsies in the pediatric population. We retrospectively analyzed a tertiary Neuropathology laboratory database to identify patients (18 years old), submitted to muscle biopsy between January