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Standard deviation reductions in TSH levels were linked to genetic risk estimates of 128 (108-152) for atrial fibrillation, 135 (106-171) for myocardial infarction, 106 (089-126) for stroke, 119 (094-152) for heart failure, 153 (103-226) for adverse vascular events, and 109 (097-123) for major adverse cardiovascular events. In a population of 105,224 individuals, low plasma thyroid-stimulating hormone (TSH) le