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Patients with type 2 diabetes and obesity, starting exenatide (a GLP-1 RA), underwent a 12-month prospective assessment of their clinical and biochemical parameters. A study of the connection between changes in body weight and serum TSH, encompassing factors related to thyroid hormone resistance, was performed. A study of 112 patients (average age 535 years, 438% female, average BMI 398 kg/m²) yielded these results.