https://www.selleckchem.com/pr....oducts/itacnosertib.
eficial protective effects against platelet aggregation and arterial thrombosis with minimal effect on hemostasis. The 12-LOX product 12(S)-HETE stimulates GPR31-Gi-signaling pathways, which enhance thrombin-PAR4 platelet activation and arterial thrombosis in human platelets and mouse models. Suppression of this bioactive lipid pathway, as exemplified by a GPR31 pepducin antagonist, may provide beneficial protective effects against platelet aggregation and arterial thrombosis with minimal effect on hemostasis. Fibrin is considered
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