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Runx2 may play a crucial role in maintaining the integrity of the dentogingival junction and the normal structure of alveolar bone. We sought to determine ****-based differences in biomarkers, self-reported health status, and magnitude of longitudinal changes in measures of reverse cardiac remodelling among patients with heart failure with reduced ejection fraction (HFrEF, left ventricular ejection fraction ≤40%) treated with sacubitril/valsartan (S/V). This was a subgroup analysis of patients initiated on S/V in the Prospective Study of B