https://www.selleckchem.com/products/GDC-0449.html
Gamma-aminobutyric acid (GABA) administration attenuates streptozotocin (STZ) induced diabetes in rodent models with unclear underlying mechanisms. We found that GABA and Sitagliptin possess additive effect on pancreatic β-cells, prompted us to ask the existence of common or unique targets of GLP-1 and GABA in pancreatic β-cells. Effect of GABA on expression of thioredoxin-interacting protein (TxNIP) was assessed in the INS-1 832/13 (INS-1) cell line, wild type (WT) and GLP-1R-/- mouse islets. GABA was also orally administrated in STZ-
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