https://www.selleckchem.com/pr....oducts/VX-680(MK-045
Amplification of MYCN is the driving oncogene in a subset of high-risk neuroblastoma. The MYCN protein and the Aurora-A kinase form a complex during S phase that stabilizes MYCN. Here we show that MYCN activates Aurora-A on chromatin, which phosphorylates histone H3 at serine 10 in S phase, promotes the deposition of histone H3.3 and suppresses R-loop formation. Inhibition of Aurora-A induces transcription-****tion conflicts and activates the Ataxia telangiectasia and Rad3 related (ATR) kinase, which limits double-strand brea
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