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Moreover, the effect of the solvent on the shuttling has been examined, suggesting that increasing the solvent polarity may weaken the directional preference of shuttling, due to the shielding effect of polar solvents on electrostatic interactions. Our study provides a theoretical framework for tuning the selectivity of directional movement in molecular machines.Towards precisely controlled nanostructure growth, patterned substrates are used as templates to direct heteroepitaxial self-assembly. This affects the size, shape and ordering of n