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Serum rheumatoid factor levels were quantified in 3474 Chinese ischemic stroke patients participating in the China Antihypertensive Trial for Acute Ischemic Stroke. Three months after the stroke onset, the primary outcome was the composite outcome of death or major disability (modified Rankin Scale score 3). To investigate the prognostic impact of genetically predicted rheumatoid arthritis (RA) and IL-6