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Expected final online publication date for the Annual Review of Phytopathology, Volume 59 is August 2021. Please see http//www.annualreviews.org/page/journal/pubdates for revised estimates.Hybrid necrosis in plants refers to a genetic autoimmunity syndrome in the progeny of interspecific or intraspecific crosses. Although the phenomenon was first documented in 1920, it has been unequivocally linked to autoimmunity only recently, with the discovery of the underlying genetic and biochemical mechanisms. The most common causal loci encode
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