https://www.selleckchem.com/pr....oducts/Irinotecan-Hc
Furthermore, we found that MyHC IIA/X-AS acts as a competing endogenous RNA (ceRNA) that sponges microRNA-130b (miR-130b) and thereby maintains MyHC IIx expression and the fast fiber muscle. We also noted that miR-130b was proved to down-regulates MyHC IIx by directly targeting its 3'-UTR. Together, the results of our study uncovered a novel pathway, which revealed that an lncRNA derived from the skeletal MyHC cluster could modulates local MyHC expression in trans, highlighting the role of lncRNAs in muscle fibe
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