https://www.selleckchem.com/pr....oducts/PD-0325901.ht
The unbound fraction (ƒ ) of ceftriaxone was 44%, and total CL was 1.27 L/h, 25-30% higher than the CL reported in septic critically ill patients not receiving renal replacement therapies, and dependent on albumin concentration and weight. Despite this increment in ƒ and CL, Monte-Carlo simulations showed that a dose of 1 g once-daily ceftriaxone is sufficient to achieve a 100% ƒ T for MICs ≤2 mg/L for any range of weight and albumin concentration. Once-daily 1 g ceftriaxone provides optimal exposure in critically ill patients with s
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