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People with a previous diagnosis of non-communicable diseases (NCDs) are more likely to develop serious forms of COVID-19 or die. Mexico is the country with the fourth highest fatality rate from SARS-Cov-2, with high mortality in younger adults. To describe and characterize the association of NCDs with the case-fatality rate (CFR) adjusted by age and **** in Mexican adults with a positive diagnosis for SARS-Cov-2. We studied Mexican adults aged ≥20 years who tested positive for SARS-Cov-2 during the period from 28 February to 31 July 2020