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This study employed single-cell RNA and B cell receptor sequencing of peripheral blood mononuclear cells to achieve the isolation and cloning of EV-A71-neutralizing antibodies. Our investigation of 145 plasmablasts yielded two IgG1 monoclonal antibodies (mAbs) and six IgM mAbs that neutralized EV-A71. The four IgM monoclonal antibodies bearing germline variable sequences effectively neutralize EV-A71. From
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