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Using peripheral blood, RNA sequencing, Illumina EPIC array-based DNA methylation assessment, and Illumina PsychArray-based genotyping were performed. In order to effectively handle the high-dimensional features of this rich multi-omic dataset, we created the integrative Geneset-Embedded non-negative Matrix factorization (iGEM) method. This method utilizes non-negative matrix factorization (NMF), combined with supplemental data on gene sets and gene-