https://s1preceptor.com/index.....php/age-related-axia
Emerging evidence suggests a link between the intestinal microbiome and the severity of sickle cell disease (SCD). Our investigation focused on whether SCD mice presented signs of intestinal barrier dysfunction, inflammatory responses, and gut dysbiosis. Using the humanized sickle cell mouse model developed by Townes, a threefold increase in intestinal permeability, as measured by the FITC-dextran (4 kDa) assay, was observed in SS (sickle cell disease) mice when compared to AA (wild-type) mic