https://www.selleckchem.com/pr....oducts/gsk-2837808A.
effectively blocked the catecholamine-induced neuroendocrine phenotypic transformation and eliminated depression-enhanced GC migration and invasion. Moreover, β -AR blocking or MACC1 silencing prevented GC metastasis attributed to a neuroendocrine phenotype in a depression mouse model. Catecholamine-induced neuroendocrine phenotypes of GC cells led to depression-accelerated GC invasion and metastasis via the β -AR/MACC1 axis, while β -AR antagonist or MACC1 silencing could reverse it, showing promising potential therapeutic strateg
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