https://www.selleckchem.com/pr....oducts/isa-2011b.htm
RAD51 facilitates ****tion fork reversal and protects reversed forks from nuclease degradation. Although potentially a useful ****tion stress response mechanism, unregulated fork reversal can cause genome instability. Here we show that RADX, a single-strand DNA binding protein that binds to and destabilizes RAD51 nucleofilaments, can either inhibit or promote fork reversal depending on ****tion stress levels. RADX inhibits fork reversal at elongating forks, thereby preventing fork slowing and collapse. Paradoxically, in the p
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