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Furthermore, small-molecule Ras•SOS disruptors fail to dissociate KRasG13D•SOScat complexes, underscoring the need for more potent disruptors. Taken together, a better understanding of the interaction between oncogenic Ras mutants and SOS will provide avenues for improved therapeutic interventions.Achieving behavioral goals requires integration of sensory and cognitive information across cortical laminae and cortical regions. How this computation is performed remains unknown. Using local field potential recordings and spectrally resolved

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The Dolce Gusto Krups Machine: An In-Depth Guide to Coffee Excellence The Dolce Gusto Krups machine is a popular option among coffee enthusiasts who value benefit without compromising quality. Known for its flexibility and ease of use, this single-serve coffee machine is designed to prepare a large range of coffee drinks varying from espresso to creamy lattes. This short article checks out the features, functionality, upkeep, and common queries associated with the Dolce Gusto Krups machine, guaranteeing that coffee fans get the most out of their bre

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The data presented in this article are related to the measurements in the contribution titled 'Tarnished silver-copper surfaces reduction using remote helium plasma at atmospheric pressure studied by means of high-resolution synchrotron x-ray photoelectron microscopy' published in Corrosion Science. X-ray photoelectron spectra were collected from pure silver, sterling silver (92.5 w% Ag and 7.5 w% Cu) alloy and pure copper. These metals were artificially sulphidised. A remote helium plasma at atmospheric pressure was applied on the m

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that increased rainfall might alter the elemental compositions of karst soils, and bacterial communities are likely to be more sensitive to variations in soil moisture in contrast to their fungal counterparts.Discovering widespread microbial processes that drive unexpected variation in carbon cycling may improve modeling and management of soil carbon (Prescott, 2010; Wieder et al., 2015a, 2018). A first step is to identify community features linked to carbon cycle variation. We addressed this challenge using an epidemiologi

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at abstinence was not effective. ISRCTN 01591254. ISRCTN 01591254. Hepatitis B virus (HBV) infection is a major public health issue worldwide, with about 257 million people reported to be chronic carriers by the WHO fact sheet updated in 2018. HBV can be contracted via direct contact with infected body fluid and infection is almost always asymptomatic. Although healthcare workers (HCWs) are at high risk of HBV infection, little is known about the prevalence of the various HBV markers among HCWs in Cameroon. The present study was taken t

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