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The wound repair of Streptozotocin-induced diabetic rats shows that diabetic wound healing is obviously accelerated by SF-MA-BS, interestingly the HIF-1a pathway is restored via interaction between HIF-1a and Cu2+, and angiogenesis is therefore enhanced. Meanwhile, inflammation is well regulated by SF-MA-BS, and long-term detrimental inflammation is avoided. These findings indicate that the SF-MA-BS hydrogel regenerates diabetic wounds, and further clinical trials are anticipated.Cannabis is a genus of flowering herbs in the Cannabacea

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Biomarker development is a key clinical research need in sickle cell disease (SCD). Hemorheological parameters are excellent candidates as abnormal red blood cell (RBC) rheology plays a critical role in SCD pathophysiology. Here we describe a microfluidic device capable of evaluating RBC deformability and adhesiveness concurrently, by measuring their effect on perfusion of an artificial microvascular network (AMVN) that combines microchannels small enough to require RBC deformation, and laminin (LN) coating on channe

https://www.selleckchem.com/pr....oducts/rhapontigenin
Spinal fracture-dislocation in the infantile population is a rare phenomenon, and its surgical management remains poorly discussed in the literature. This article reports a case of traumatic fracture-dislocation in an infant by outlining the surgical management and extensively reviewing the literature. An 8-month-old girl was involved in a motor vehicle accident and was ejected from the car through the windshield. Radiological imaging demonstrated a complete spinal cord injury at the level of T10 and a three-column fracture of T12

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0, standard deviation = 7.3). Predictors of preparedness included having a pediatrician on the hospital disaster planning committee, conducting a disaster exercise that simulated an unaccompanied minor scenario, and implementing the 2018 American Academy of Pediatrics Reunification Planning Tool. Findings from this study indicate that many US hospitals are not prepared to reunify unaccompanied minors or other separated family members during a disaster. The planning tool is a free resource that hospitals can use to improve their hos

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Foveal thickness and macular volume for the children below 6 years were significantly lower than for the older group. Significant correlation was found for contrast sensitivity, foveal thickness and macular volume with age and between contrast sensitivity and foveal thickness. Our data suggest that the developmental processes at the retina and visual cortex occur in the same age range. Thus, in parallel to maturation of the PF, which enables reduction in crowding, foveal development contributes to increasing contrast sensitivity. In low

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Hypertension is mainly managed in primary care. Shared decision making is widely recommended as an approach to treatment decision making. However, no studies have investigated; in detail, what happens during primary care consultations for hypertension. To understand patients' and clinicians' experience of shared decision making for hypertension in primary care, in order to propose how it might be better supported. Longitudinal qualitative study. Five general practices in south-west England. Interviews with a purposive sample

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We have studied, in diabetic older adults with urinary retention (UR), whether a urinary catheter (UC) inserted during hospitalization but not removed is associated with 1-year mortality. A retrospective study included 327consecutive older adults (age ≥ 65years; median age 83years; 57.8% males) with UR in whom a UC was inserted during hospitalization 139 (42.5%) diabetics and 188 (57.5%) nondiabetics. UC removal rates during hospitalization and 1-year mortality rates were studied in both groups. Cox regression analy

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ies in lower- and middle-income countries to explore its causes so that targeted strategies can be developed to address this issue. University students are at significantly higher risk of serogroup B meningococcal (Men infection, which can result in debilitating sequelae and excessive healthcare usage. This study aimed to elucidate the impact of universal pre-enrollment vaccination on MenB outbreak probability and the cost-effectiveness in outbreak-only scenarios. We developed an infectious disease transmission model to determine the