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BACKGROUND Most skin and soft tissue infections (SSTIs) are managed in the outpatient setting, but data are lacking on treatment patterns outside the emergency department (ED). Available data suggest there is poor adherence to SSTI treatment guidelines. METHODS We conducted a retrospective cohort study of Veterans diagnosed with SSTIs in the ED or outpatient clinics from 1/1/2005-6/30/2018. The incidence of SSTIs over time was modeled using Poisson regression using robust standard errors. Antibiotic selection and incision and drainage (I