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Our results demonstrate for the first time that a polyphenolic extract from cocoa and its main flavonoid protect human endothelial cells against an oxidative insult by modulating oxygen radical generation and antioxidant enzyme and non-enzyme defences.PURPOSE The β2-adrenergic receptor (β2AR) is highly expressed in various human cancers. The prognostic significance of its expression in patients with colorectal cancer (CRC) remains unclear. The aim of this study was to assess the prognostic role of β2AR expression in patients with surgi

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best registered agent for compliance The role of a resident agent might seem straightforward, but choosing the right one can significantly impact your business operations. They are responsible for receiving legal documents and notifications of lawsuits, which means they need to be reliable, accessibl

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trix from the standpoint of physical chemistry of polymer as quasi-equilibrium, thermodynamically limited ordered system of biopolymers. Thus, the biochemical processes of synthesis and self-organization lead to the formation of a complex multicomponent system of wood substance, considered as a nanobiocomposite. This determines the need to study the applicability of the fundamental cycle "structure-functional nature-properties" from the standpoint of physical chemistry of biopolymers both for the investigation of pl

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Despite their high potency, the widespread implementation of natural antimicrobial peptides is still challenging due to their low scalability and high hemolytic activities. Herein, we address these issues by employing a modular approach to mimic the key amino acid residues present in antimicrobial peptides, such as lysine, leucine, and serine, but on the highly biocompatible poly(ethylene glycol) (PEG) backbone. A series of these PEG-based peptides (PEGtides) were developed using functional epoxide monomers, corresponding to each key am

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Photodynamic therapy (PDT) is a promising new method to eliminate microbial infection and promote wound healing. Its effectiveness has been confirmed by some studies; however, the mechanisms of PDT in wound healing remain obscure. We used mouse skin wounds infected with Pseudomonas aeruginosa as a research object to explore the therapeutic effects and mechanisms of 5-aminolevulinic acid photodynamic therapy (ALA-PDT). ALA-PDT treatment significantly reduced the load of P. aeruginosa in the wound and surrounding tissues and

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This paper describes a selenium-promoted electrophilic cyclization of arylpropiolamides allowing the synthesis of 3-organoselenyl spiro[4,5]trienones via a 5-endo-dig ipso-mode. The 3-organoselenyl-quinolinone derivative formation via 6-endo-dig was avoided using an electrophilic organoselenium species in a metal-free protocol. The use of phenylselenyl bromide (1.3 equiv.), as the electrophilic source, in nitromethane (3 mL) at 90 °C enabled the cyclization of N-(2-methoxyphenyl)-N-methyl-3-phenylpropiolamides, giving 3-organoselenyl[4,5

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Studies on the association between urinary albumin to creatinine ratio (ACR) and bone mineral density (BMD) are still controversial. This study investigated the association between ACR and BMD in the general US population. This cross-sectional study identified 2007 individuals aged 40 or above years with complete and valid data on urinary albumin to creatinine ratio (ACR) and femoral neck, total femur and lumbar spine BMD from the National Health and Nutrition Examination Survey 2013-2014. ACR was directly measured with established me

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05 for both). The median OMEs prescribed did not increase during the washout phase. Prostatectomy patients discharged with opioids had higher levels of anxiety than patients discharged without opioids (P .05). Otherwise, prostatectomy and nephrectomy patients discharged with and without opioids did not differ in their perception of postoperative pain management, activity levels, psychiatric symptoms, or somatic symptoms (P .05 for all). Implementing a multipronged behavioral intervention significantly reduced o

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Affordable Sofas in the UK: Finding the Perfect Balance Between Style and Budget When it comes to furniture shopping, the sofa is often the centerpiece of a living-room. It's where friends and family gather, making it an essential piece for both convenience and design. Nevertheless, with the myriad alternatives available, discovering an affordable sofa in the UK that doesn't compromise on quality can be a challenging task. intends to assist purchasers through the intricacies of purchasing an affordable sofa without sacrificing on