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We established a reliable method for the evaluation of anaphylactoid reactions induced by complex compounds, using multiple physiological indicators, different experimental models in vivo and in vitro. BACKGROUND Neuronal ceroid lipofuscinosis (NCL) is a hereditary lysosomal storage disease with progressive brain neurodegeneration. Mutations in ceroid lipofuscinosis neuronal protein 5 (CLN5) cause CLN5 disease, a severe condition characterized by seizures, visual failure, motor decline, and progressive cognitive deterioration. This stud

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Türkiye şans oyunları sektörü, günümüzde büyük bir ivme kazanarak oldukça popüler hale gelmiştir. 2025 yılı itibarıyla, online bahis ülkemizde farklı imkanlar sağlayan web siteleriyle doldurmaya devam etmektedir. Hem spor bahisleri Türkiye'de hem de canlı şans oyunları Türkiye gibi özellikle popüler alanlarda, kullanıcılar için pek çok olanağı bulunuyor. O halde, bu alanda en iyi şans oyunları siteleri hangileri? Emniyetli ve yükse

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Oxidative stress and mitochondrial dysfunction have been associated with valproic acid (VPA) induced neurotoxicity. Mitochondria are vulnerable to oxidative damage and are also a major source of superoxide free radicals. Therefore, the need for mitochondrial protective and antioxidant agents for reducing valporic acid toxicity in central nerve system (CNS) is essential. In the present study, we investigated the potential beneficial effects of sodium selenite (SS) and L-carnitine (LC) against valproic acid -ind

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Cardiac arrest is the leading cause of death among patients receiving hemodialysis. Despite guidelines recommending CPR training and AED presence in dialysis clinics, rates of CPR and AED use by dialysis staff are suboptimal. Given that racial disparities exist in bystander CPR administration in non-healthcare settings, we examined the relationship between patient race/ethnicity and staff-initiated CPR and AED application within dialysis clinics. We analyzed data prospectively collected in the Cardiac Arrest Registry to Enhance Survival

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2025 yılına girdiğimizde, Türkiye'de bahis sektörü süratle büyümeye devam ediyor. Online bahis Türkiye pazarındaki büyüme, kullanıcıların Gelişmiş bir bahis deneyimi yaşaması için tezgahta sunulan bir fırsat sağlıyor. Artık, spor bahisleri Türkiye'de daha erişilebilir, emniyetli ve farklı hale geldi. Ancak, bu sert rekabet atmosferinde en kaliteli bahis sitelerini bulmak ve kaliteli hizmet sunan siteler ulaşmak da bir o kadar ciddi. Resmi bahis siteleri Türkiye'de artan bir itimatla tercih ediliyor. Kullanıcılar,

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Evidence comparing fibrin sealants (FSs) in surgery are limited. This study evaluated the efficacy and safety of FSs, and manual compression in peripheral vascular surgery. A systematic review of randomized trials was conducted in Medline, Embase, and Cochrane databases within the last 15 years. Data were available to conduct a network meta-analysis (NMA) in peripheral vascular surgery. Fibrin sealant treatment arms were further broken-down and assessed by clotting time (i.e., 2-min [2C] or 1-min [1C]). The primary efficacy outcome was

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Implications are considered for utilizing theoretical and applied insights from the model to cultivate resilience in face of adversity and suffering.With the increasing prevalence of Internet usage, Internet-Delivered Psychological Treatment (IDPT) has become a valuable tool to develop improved treatments of mental disorders. IDPT becomes complicated and labor intensive because of overlapping emotion in mental health. To create a usable learning application for IDPT requires diverse labeled datasets containing an adequate set of linguist