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Germinal centers play a key role in the adaptive immune system since they are able to produce memory B cells and plasma cells that produce high affinity antibodies for an effective immune protection. The mechanisms underlying cell-fate decisions are not well understood but asymmetric division of antigen, B-cell receptor affinity, interactions between B-cells and T follicular helper cells (triggering CD40 signaling), and regulatory interactions of transcription factors have all been proposed to play a role. In addition, a temporal switch

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COVID-19 continues to threaten human life worldwide. We explored how human behaviours have been influenced by the COVID-19 pandemic in Hong Kong, and how the transmission of other respiratory diseases (e.g. influenza) has been influenced by human behaviour. We focused on the spread of COVID-19 and influenza infections based on reported COVID-19 cases and influenza surveillance data, and investigated the changes in human behaviour due to COVID-19 based on mass transit railway data and the data from a telephone survey. We did the simulati

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Phytoremediation is an essential technique for mines' ecological restoration. Modifiers addition can alleviate the stress of heavy metals to plants and enhanced remediation efficiency. Herein, spent mushroom compost (SMC) and calcium carbonate (CaCO3) were added to lead-zinc mine tailings to reveal the mechanism of Macleaya cordata adaptive to heavy metals stress. Pot experiments were conducted in 100% tailing (T), 90% tailing + 5% SMC + 5% CaCO3 (T+), and 100% natural soil (NS). The results indicate that SMC and CaCO3 amendments could imp

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 To compare early implant failure and implant stability of one-stage Hiossen ET III implants with its new hydrophilic (NH) surface, compared with Hiossen ET III implants with the sandblasted and acid-etched (SA) surface at 1-year follow-up.  This study was designed as a split-mouth, multicenter randomized controlled trial aimed to compare SA surface implants (SA group) and NH surface, (NH group). Outcomes were implant and prosthetic survival rates, complications, the insertion torque at implant placement, and implant stability quotient (

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3%, 95% CI, 31.1-72.6%; culture 60.9%, 95% CI, 38.8-79.5%). In clinical TB cases, mNGS detected additional positive results (40.6%, 26/64). mNGS reduced the turnaround time from 2-6 weeks to 32-36 hours. mNGS may be a promising technology for the early auxiliary diagnosis of active TB, especially sputum-negative pulmonary TB (PT and tuberculous serous effusion. mNGS may be a promising technology for the early auxiliary diagnosis of active TB, especially sputum-negative pulmonary TB (PT and tuberculous serous effusion. Path

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1% identified two or more such practices. The researchers perceived a high prevalence of duplicate publication (66.5%) and self-plagiarism (59.0%), use of personal influence (57.5%) and citation manipulation (44.0%), in contrast to a low perceived incidence of data falsification or fabrication (10.0%). The debate and the interviews corroborated these data. Researchers associated the spread of these misconducts with the research evaluation model applied in Spain. Dose reduction achieved by downsizing the field of view (FOV) in CBCT scans

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In addition, most symptoms increased over time since deployment regardless of exposure. We aimed to investigate differences between high-intensity interval exercise (HIIE, including high-intensity interval training and sprint interval training) and moderate-intensity continuous training (MICT) on physical fitness, body composition, blood pressure, blood lipids, insulin and glucose metabolism, inflammation, and endothelial function. Differences between HIIE and MICT were summarized using a random-effects meta-analysis on the effect siz

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We demonstrated a significant increase in terms of exceeding the reference values of TGF-β1 (37.5% vs 8.8%) and MBP (75% vs 35.3%) in patients with SR compared to the non-SR group (qualitative analysis). There was also a statistically significant increase in the concentration of each of the determined biomarkers (quantitative analysis) in the SR group. The increase in TGF-β1 and MBP concentrations indicates the inflammatory and probably fibrostenotic pathogenesis of SR. Obtained results do not allow for an unequivocal

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A mechanism of nanocavitation via interstitial oxygen generation mediated by multiphoton and avanlanche defect ionization is proposed. We demonstrate ultralow-loss geometrical phase optical elements, including geometrical phase prism and lens, and a vector beam convertor in silica glass. © The Author(s) 2020.Direct femtosecond (fs) laser processing is a maskless fabrication technique that can effectively modify the optical, electrical, mechanical, and tribological properties of materials for a wide range of po

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를 처음 경험하시는 고객들은 많은 궁금한 점이 있을 수 있습니다. 특히 어떤 방법으로 진행이 되는지에 대해, 어떠한 준비가 필요하는지 필요한지 , 주의해야 할 점은 무엇인지 물음이 자주 따릅니다. 출장마사지 서비스 서비스는 편리함을 함께 다양한 혜택을 제공하므로, 많은 수요가 있어지고 있습니다. 이 글에서는 특별히 출장 마사지의 전반적인 진행 과정을 상세하게 설명하겠습니다. 준비물에서 시작합니다, 마사지 받는 수법 주의사항까지 하나하나씩 살펴보겠습니다 여러분의 질문에 답변해드릴 예정입니다. 출장 마사지가 처음 이용하시는 사람들도 걱정하지 않으시도록 서비스를 이용하실 수 있도록. 출장 마사지를 개념 출장 마사지는 고객이 요청한 장소로 마사지사를 보내어 수행하는 서비스입니다 일반적으로 출장 마사지는 호텔, 사무실, 또는 개인의 집과 같은 편안한 환경에서 제공됩니다. 이 서비스는 바쁜 일상 속에서 시간 절약 , 원하는 장소에서 편안하게 마사지 서비스를 받을 수 있는 장점이 있습니다. 본 서비스는 각종 마사지 기술을 활용하여 스트레스