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Warsaw breakage syndrome (WABS) is a genetic disorder characterized by sister chromatid cohesion defects, growth retardation, microcephaly, hearing loss and other variable clinical manifestations. WABS is due to biallelic mutations of the gene coding for the super-family 2 DNA helicase DDX11/ChlR1, orthologous to the yeast chromosome loss protein 1 (Chl1). WABS is classified in the group of "cohesinopathies", rare hereditary diseases that are caused by mutations in genes coding for subunits of the cohesin c

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009) in estrogen-receptor positive (ER+) patients with cancer. The results suggested that plasma anti-PRA IgG levels may be a useful prognostic marker for monitoring PPVs, particularly for ER+ patients with mrBC (trial registration no. from the UMIN Clinical Trials Registry, UMIN000001844). To investigate the long-term survival of patients with primary Sjögren's syndrome (pSS) in China. Patients with pSS who fulfilled the 2002 American-European Consensus Group classification criteria were prospectively enrolled from 2004 to 2011. Their

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.30, P 0.01), so as serum IL-6 (ng/L 15.55±3.77 vs. 32.22±3.84) and lung IL-6 mRNA expression (2 0.79±0.21 vs. 6.89±0.92, both P 0.01). The mRNA expressions of GRP78, PERK and CHOP were also significantly decreased [GRP78 mRNA (2 ) 1.90±0.16 vs. 7.55±1.29, PERK mRNA (2 ) 1.68±0.20 vs. 4.54±0.89, CHOP mRNA (2 ) 1.13±0.24 vs. 4.44±1.13, all P 0.05], and the protein expressions of GRP78, PERK, ATF6 and CHOP were significantly decreased (GRP78/GAPDH 0.59±0.02 vs. 0.77±0.01, PERK/GAPDH 0.48±0.03 vs. 1.04±0.05, ATF6/GA

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ed comparable effectiveness and safety in the treatment of gastric diseases in our meta-analysis. Based on the current evidence, we believe that RPLS is an efficacious surgical alternative to CMPLS in the management of gastric diseases because of the shorter hospital stay and reduced blood loss. However, large-scale, well-designed, multicenter studies are needed to further confirm the results of this study. Bile acid is an essential factor that plays a role in metabolic regulation, but how bile acid is regulated after Roux-en-Y gastr

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Melanocytic nevi have a complex evolution influenced by several endogenous and exogenous factors and are known risk factors for malignant melanoma. Interestingly, tobacco use seems to be inversely associated with melanoma risk. However, the association between tobacco use and nevi and lentigines has not yet been evaluated. We investigated the prevalence of nevi, atypical nevi, and lentigines in relation to tobacco smoking in a cohort of 59 smokers and 60 age- and ****-matched nonsmokers, using a questionnaire and performing a total body

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STUDY DESIGN Retrospective chart analyses as part of a quality improvement project. OBJECTIVES To demonstrate treatment of pressure injury (PI) in patients with spinal cord injuries (SCI) and analyse costs using the "modified Basel Decubitus Concept". SETTING Inpatient setting of a specialised acute care and rehabilitation clinic for SCI. METHODS Complex treatment courses of four patients with chronic SCI and PI stage III or IV were described and costs were recorded. The total healthcare services' costs per patient and different profess

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Our findings provide a theoretical target basis for the treatment of prostate cancer.This multicenter study presents prevalence data and associated risk factors of post-COVID-19 cough one year after hospital discharge in COVID-19 survivors. Individuals recovered from COVID-19 at three public hospitals in Madrid (Spain) were scheduled for a telephonic interview. They were systematically asked about the presence of respiratory symptoms, e.g., fatigue, dyspnea, chest pain, and cough after hospital discharge. Clinical and hospitalization data

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Initially, Alma Laser (Israel) applied fractional CO2 laser therapy, using energy levels ranging from 360 millijoules to 1008 millijoules. A 6 MeV, 900 cGy electron beam was used to irradiate the sample twice consecutively. Within 24 hours post-laser therapy, the initial pass was made, and the second pass was executed on the seventh day after the laser therapy. Before and at 6, 12, and 18 months after the treatment, the patient's lesions were measured according to the POSAS scale. Upon each follow-up v