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The D251R mutant displayed higher catalytic activity than the wild-type in the pH range 6.5-7.5, and further insight into those shorter and newly formed hydrogen bonds in substrate docking analysis could account for the higher bind affinity and catalytic efficiency of D251R mutant. The D251R mutant displayed higher catalytic activity than the wild-type in the pH range 6.5-7.5, and further insight into those shorter and newly formed hydrogen bonds in substrate docking analysis could account for the higher bind affinity and catalytic effici

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We here describe the potential COVID-19 associated risks and therapeutic considerations for patients with distinct inherited arrhythmia syndromes and provide recommendations, pending local possibilities, for their monitoring and management during this pandemic. BACKGROUND Congenitally corrected transposition of the great arteries (CCTGA) is associated with spontaneous AV block and pacing-induced cardiomyopathy. His bundle pacing (HBP) is a potential alternative to conventional CRT. OBJECTIVES To determine the outcomes of HBP for CCTGA. METHOD

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The traditional Chinese medicine Caulis Sargentodoxae is widely used in the treatment of ulcerative colitis (UC), but the mechanism remains unknown. The present study aims to reveal its effective components, targets and pathways through network pharmacology and bioinformatics approaches. Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was used to identify effective components. The ligand-based targets prediction was achieved through SwissTargetPrediction and TargetNet. UC-related targets were i

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Wood Burning Fireplaces in the UK: A Comprehensive Guide Wood burning fireplaces have actually long been a staple of warmth and beauty in homes across the UK. The crackling sound of burning wood and the flickering of flames develop an inviting environment, transforming a home into a warm sanctuary. With the growing trend of eco-friendly heating services, wood burning fireplaces are ending up being increasingly popular once again. This short article provides a thorough take a look a

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t can be proactively implemented and selectively applied to facilitate improved recruitment outcomes.The COVID-19 pandemic has driven a greater reliance on telemedicine, yet rural access, use, and satisfaction with telemedicine and the role of eHealth literacy are unknown. Using a cross-sectional design, 279 (70.6% female) western rural Canadians completed an online survey. The majority of participants reported access to telemedicine, but nearly 1/5 lacked access to online or virtual mental health services. The majority of participants

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We also identified over-presented microbial functional traits mediating plant-microbe and microbe-microbe interactions, nutrition acquisition, and plant growth promotion in P. notoginseng rhizosphere. Our findings provide a valuable reference for studying beneficial microbes and pathogens of P. notoginseng planted in DT and LX.In selective RNA processing and stabilization (SRPS) operons, stem-loops (SLs) located at the 3'-UTR region of selected genes can control the stability of the corresponding transcripts and determine the stoichio

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A Lewis acid-promoted [6+1] annulation between sulfur ylides and modified vinyl benzoxazinanones was described. In this reaction, the newly designed vinyl benzoxazinanones could serve as a novel six-atom synthon, and the key to success is the installation of an electron-withdrawing group on the alkene moiety of the benzoxazinanones. A broad range of substrates are compatible with this mild reaction system, thereby providing a facile and practical approach for constructing a benzo[b]azepine skeleton.Following the COVID-19 outbreak, swabs for biological speci