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Use of a urinary catheter balloon tamponade (UCBT) in controlling traumatic hemorrhage is a frequently employed but infrequently described technique. We aim to discuss the experience of balloon tamponade as a bridge to definitive hemorrhage control in the operating room. This is retrospective review at a single institution from January 2008 to December 2018. We identified patients with active bleeding from penetrating torso trauma in whom UCBT was used to tamponade bleeding. We used revised trauma score (RTS), injury severity score (ISS

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Therefore, this chapter will present the main validated biological targets of the genus Schistosoma, as thioredoxin glutathione reductase (TGR), histone deacetylases (HDAC 1, HDAC 8), dihydroorotate dehydrogenase, sirtuin protein and cathepsin L1, as well as reports of CADD in literature applied to the development of drugs against schistosomiasis, providing compounds with high pharmacological potential and high specificity.Praziquantel is a remarkably effective drug for the treatment of schistosomiasis. It has few side effects, some

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The objective of this review is to chart the evidence relating to food security among African Canadian communities to inform future research and offer insight related to food security in African Canadian communities. Achieving food security is of global importance in the attainment of the United Nations Sustainable Development Goals. As a social determinant of health, food security, which refers to the unrestricted physical, economic, and timely access to safe and nutritious foods, impacts over four million Canadians. Yet

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Therefore, Green Lindoblum and Green Pegassos will be useful tools that detect specific molecules in clinical use and monitor the interplay of metabolites and other related molecules in diverse cell types.The complete genome sequence of a novel circovirus (elk circovirus (ElkCV) Banff/2019) was determined via high throughput sequencing of liver tissue from a euthanized Rocky Mountain elk (Cervus canadensis nelsoni) from Alberta, Canada. The genome is circular and 1,787 nucleotides long, with two major ORFs encoding predicted

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In contrast, RAB43 overexpression promoted proliferation and metastasis in normal gastric epithelial GES‑1 cells. In vivo studies confirmed that RAB43 promoted tumor growth. In addition, the knockdown of RAB43 significantly inhibited cell proliferation and metastasis via phosphatidylinositol-3-kinases/protein-serine-threonine kinase (PI3K/AKT) pathway. Conclusion RAB43 promotes GC cells proliferation and migration in vivo and in vitro and probably served as a novel potential therapeutic biomarker for GC. © 2020 Huang

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As such, we found that intra-epidermal stimulation with a multisine frequency modulated pulse sequence can generate nociceptive SSEPs. The possibility to stimulate the nociceptive system using multisine frequency modulated pulses offers novel opportunities to study the temporal dynamics of nociceptive processing. SARS-CoV-2 quick testing is relevant for the containment of new pandemic waves. Antigen testing in self-collected saliva might be useful. We compared salivary and naso-pharyngeal swab (NPS) SARS-CoV-2 antigen detection by

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Appropriate psychological interventions are necessary, and changes in immune function should be emphasized during long-term follow up of these patients.Purpose This study reports predictive dosimetric and physiologic factors for fat necrosis after Stereotactic-Partial Breast Irradiation (S-PBI). Materials and methods Seventy-five patients with ductal carcinoma-in-situ or invasive nonlobular epithelial histologies stage 0, I, or II, with tumor size less then 3 cm were enrolled in a dose escalation Phase I S-PBI trial between January 201

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In vitro studies using TGFβ3-deficient fibroblasts in 3-D collagen lattice formation assays indicated that TGFβ3 was required for collagen matrix reorganization. Biochemical studies indicated the 'paradoxically' increased activation of canonical (SMAD-dependent) and noncanonical (MAP kinase-dependent) pathways. TGFβ3 is required for cardiovascular development to maintain a balance of canonical and noncanonical TGFβ signaling pathways.Glutamic acid decarboxylase (GAD) is an intracellular enzyme whose physiologic function is the d

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Combining of these parameters had the following findings CRP + ferritin; AUC 0.77 with 55% sensitivity and 97% specificity, Ferritin + LDH; AUC 0.83 with 65% sensitivity and 92% specificity, CRP+LDH; AUC 0.78 with 56% sensitivity and 98% specificity, CRP + LDH + ferritin; AUC 0.85, with 73% sensitivity and 88% specificity, CRP + LDH + ferritin + D dimer; AUC 0.85 75% sensitivity and 87% specificity. Combination of routine laboratory biomarkers (CRP, LDH and ferritin ±D dimer) can be used to predict the diagnosis of COVID-19

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Titanium dioxide (TiO2) is increasingly being used in biosensing applications. Herein, we review the most recent developments in photoelectrochemical (PEC) and electrochemiluminescent (ECL) biosensing based on TiO2 nanomaterials, as well as the mechanisms that lead to the improved performance of biosensors that incorporate these nanomaterials. The merits of TiO2-based ECL and PEC biosensing strategies are summarized by highlighting some illustrative examples that have been reported within the last 5 years. The future prospects for