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Colorectal cancer risk in middle-aged Japanese adults was not found to be related to their sugar intake. The potential for an increased risk of rectal cancer in women consuming significant quantities of total sugar cannot be definitively ruled out. Corneal epithelium renewal originates from limbal stem/progenitor cells (LSC). The regulatory mechanisms governing LSC proliferation and differentiation are critical for maintaining corneal homeostasis, but remain large

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[This corrects the article DOI 10.3389/fphys.2019.01432.].Introduction Chronic exposure to the weightlessness-induced cephalad fluid shift is hypothesized to be a primary contributor to the development of spaceflight-associated neuro-ocular syndrome (SANS) and may be associated with an increased risk of venous thrombosis in the jugular vein. This study characterized the relationship between gravitational level (Gz-level) and acute vascular changes. Methods Internal jugular vein (IJV) cross-sectional area, inferior ve

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Cumulatively, our data suggested CcSMC4p function was required for dinoflagellate S-phase progression, and we propose that condensin-mediated higher-order compaction provisioning is involved in the provision of local rigidity for the replisome.Although gene-environment interactions are known to play an important role in the inheritance of complex traits, it is still unknown how a genotype and the environmental factors result in an observable phenotype. Understanding this complex interaction in the pathogenesis of diabetic

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Altogether, these findings provide the rationale to further investigate the potential actions of HCT and PR extracts against breast cancer in vivo.Fruit and vegetable consumption may protect against sarcopenia but there are no studies on this topic from low- and middle-income countries (LMICs). Thus, we assessed this association among older adults from six LMICs. Community-based cross-sectional data of the Study on Global Aging and Adult Health were analyzed. Sarcopenia was defined as the presence of low skeletal muscle

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To further characterize seven compounds, their potential to inhibit gametocyte activation or induce cytotoxicity in formed zygotes was evaluated. Further validation of these results was achieved via Plasmodium falciparum and P. vivax mosquito membrane-feeding assays. This study showcases that the application of high-throughput screens, using the Ookluc line, identifies compounds that are active against the two most crucial Plasmodium species affecting humans. This provides a list