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We also find that loss of Fbxw7 is linked to the acquisition of Trp53 mutations, similar to the mutational spectrum observed in patients. Our results demonstrate that the loss of Fbxw7 promotes the acquisition of Trp53 mutations and that the two cooperate in breast tumor development. Targeting c-Myc, E2F, or p53 may therefore be a beneficial treatment strategy for FBXW7-altered breast cancer patients. Competitive swimmers incur shoulder pain and injury. Physical characteristics such as shoulder range of motion (ROM) and endurance and t

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Automatic dosing of hemodynamic drugs in the controlled DCD context has the potential to prevent onset of IMC up to [Formula see text], enabling ethical and medically safe organ procurement. This has the potential to increase the use of DCD heart transplantation, which has been widely recognized as a means of meeting the growing demand for donor hearts. Automatic dosing of hemodynamic drugs in the controlled DCD context has the potential to prevent onset of IMC up to [Formula see text], enabling ethical and medically safe

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Modern office decor is a way to make your work space reflect the culture of your company and encourage productivity. The right office decorations can also add a pop of personality to an otherwise neutral room, whether you're working at a corporate headquarters or in your own home office. Using a combination of decorative pieces and practical organizational accessories, you can create an aesthetically pleasing space that makes the job feel more fun. The Entryway Create a welcoming atmosphere for your employees and clients with an inviting entr

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With regards to short-term survival, top model had metrics AUROC = 0.937, accuracy = 86%, specificity = 88%, sensitivity = 85%, NPV = 85%, and PPV = 87%. For long-term survival, the top model had AUROC = 0.893, accuracy = 81%, specificity = 79%, sensitivity = 83%, NPV = 82%, and PPV = 79%. The top intermediate-term survival prediction had AUROC ≥ 0.780 and the other metrics were at least 70%. Our ensemble models were high-performing and achieved AUROCs as high as 0.94, highlighting the importance of balancing, using ensemble techni

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001 and .004, respectively). Among lung transplant recipients with positive donor respiratory cultures, short-course perioperative antibiotics were as effective as long-course antibiotics in preventing donor-derived bacterial respiratory infections. As minimally invasive spine surgery becomes more widespread, concerns regarding radiation exposure to surgeons and patients alike have become a growing concern. Robotic guidance has been developed as a way to increase the accuracy of instrumentation while decreasing radiation burden. A ret

Fiber lazer kesim, metal işleme sektöründe en gelişmiş teknolojilerden biridir. Yüksek yoğunluklu lazer ışınları sayesinde hızlı ve hassas kesimler gerçekleştirilebilir. Bu teknoloji, paslanmaz çelik, alüminyum ve bakır gibi metallerin işlenmesinde büyük kolaylık sağlar. CNC lazer sistemleri ile birleştiğinde, üretim süreçlerini önemli ölçüde hızlandırır. Fiber lazer kesim, düşük enerji tüketimi ve uzun ömürlü lazer kaynakları sayesinde maliyetleri düşürür. Ayrıca, minimum malzeme israfı ile çevre dostu bir üretim yöntemi sunar. Otomotiv, havacılık ve medikal sektörlerinde yaygın olarak kull

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6 dB cm2 g-1) and high in-plane thermal conductivity (15.53 W m-1 K-1), simultaneously. More interestingly, the sandwich film also reveals outstanding solar-thermal energy conversion ability, which guarantees its normal function in extremely cold environment. The unique asymmetric sandwich structure provides a new strategy for designing and preparing high-performance EMI shielding and thermal conductive films.Drug carriers capable of releasing multiple protein therapeutics in an appropriate sequence are highly desirable for the treatmen

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Homocysteine, a risk factor for cardiovascular disease, is commonly analyzed using enzymatic measurements and immunoassays. We compared the results of a new enzymatic assay with those of an immunoassay, using new reagents for homocysteine. The 87 serum samples were analyzed using the Abbott Architect i2000sr (immunoassay) and Toshiba TBA-c16000 (enzymatic assay), and the results obtained from the two assays were compared for precision, correlation, linearity, sample carryover, and reference range verification according to the Clinica

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6%) were regarded as novel potentially predictive mutations. Of the nine functionally validated novel mutations, EGFR Y1069C and ERBB2 E936K were transforming in Ba/F3 cells and demonstrated enhanced signaling activity. Mechanistically, the EGFR Y1069C mutation disrupted the binding of the ubiquitin ligase c-CBL to EGFR, whereas the ERBB2 E936K mutation selectively enhanced the activity of ERBB heterodimers. These findings indicate that integrating data from publicly available cell line databases can be used to identify novel, predictive n