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Debilitating mental illness like depression and related mood disorders is due to the disruption in circuitry that controls emotion, motivation, and reward, characterized by disparate phenotypes like decrease in socialization, motivation, threshold for threat apprehension, etc. Chronic stress is a major factor in the etiology of these disorders. Here, using a chronic unpredictable stress (CUS) paradigm the characterization of an array of mood disorder phenotypes in adult zebrafish, in comparison to normal control unstressed fish, was ach

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Ergosterol, a terpenoid compound produced by fungi, is an economically important metabolite serving as the direct precursor of steroid drugs. Herein, ergsosterol biosynthetic pathway modification combined with storage capacity enhancement was proposed to synergistically improve the production of ergosterol in Saccharomyces cerevisiae. S. cerevisiae strain S1 accumulated the highest amount of ergosterol [7.8 mg/g dry cell weight (DCW)] among the wild-type yeast strains tested and was first selected as the host for subsequent metabolic en

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Amidst the dynamic world of internet gaming, slot games continue to hold a cherished place in the hearts of enthusiasts. With innovative features and engaging themes, the most recent online slots are designed to provide thrilling experiences that keep us revisiting for more. One of the most exciting aspects of these games is their bonus features, which can significantly enhance gameplay and offer attractive rewards. As players seek the finest slot games that not only entertain but also deliver rewarding oppor

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The KMD (kinetically-derived maximum dose) is an increasingly advocated concept that uses toxicokinetic data in the top dose selection for toxicity testing. Application of this concept may have serious regulatory implications though, especially in the European Union. The basic assumption is that the relationship between internal and external dose (IED) shows an inflection point where linearity transits into non-linearity due to saturation of underlying processes; top doses in toxicity tests should not be above the inflection point, provided

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A review of patient data for suspected COVID-19 cases occurred between March and June 2020 (spanning four months). This involved assessing demographics, clinical aspects, hospitalisation duration, and associated financial outlays. Our research data indicated that, during the period in question, a total of 190 individuals, with a median age of 58, were diagnosed with COVID-19. Among the cohort of patients evaluated, 21 demonstrated a positive PCR result and 56 exhibited clini

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สล็อตปั่นได้ทุกที่ที่ต้องการ ที่เล่นแล้วยิ่งเล่นยิ่งสนุก แถมเงินเข้ากระเป๋าแบบจัดหนัก ถ้าหากคุณยังมิได้ทดลองเล่นสล็อตตรงนี้ นับว่าพลาดมากมาย เนื่องจากไม่ใช่แค่เกมที่รื้นเริง สล็อต ฝากถอน เว็บไซต์ตรง แต่ว่าโบนัสก็มีมาแจกกันแบบไม่ยั้ง ไม่ว่าจะเป็นฟรีสปิน, โบนัสเงินออม, และยังรวมไปถึงแจ็คพอตขนาดใหญ่ที่แตกกระจายได้ตลอดระยะเวลา ทดลองดูสิว่าเงินแรกจะเปลี่ยนเป็นใช่หรือฝันในมือคุณ เล่นไปเพลิดเพลินๆมั่งคั่งได้อย่างไม่ยากเย็นใครกันแน่จะไม่ได้อยากต้องการทดลองล่ะ ค่ายสล็อตที่เยี่ยมท

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CRISPR-mediated genome editing has undoubtedly revolutionized genetic engineering of animals. With the ability for virtually unlimited modification of almost any genome it is easy to forget which amazing discoveries paved the way for this ground-breaking technology. Here, we summarize the history of genome editing platforms, starting from enhanced integration of foreign DNA by meganuclease-mediated double-strand breaks to CRISPR/Cas9, the leading technology to date, and its re-engineered variants.The workplace provides an importan

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In contrast, many TOC and TIC genes are rapidly induced by blue light in both WT and the ppi2 mutant. We uncovered that this regulation is mediated primarily by cryptochrome 1 (CRY1). Furthermore, deficiency of CRY1 resulted in the decrease of some TOC proteins in vivo. Our results suggest that CRY1 plays key roles in optimizing the content of the TOC-TIC apparatus to accommodate the import of abundant photosynthesis-associated proteins during photomorphogenesis.We aim to generate an artificial neural network (ANN) model

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Treatment discontinuation had a positive effect on the weight and metabolic changes observed in FEP patients; however, this effect was not sufficient to reaching a complete reversal to normal levels. It is important to understand the mode of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for disease control. We aimed to clarify how soon SARS-CoV-2 transmission can occur after infection by asymptomatically infected individuals. We analyzed the publicly available epidemiological information for a cluster o


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