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Docetaxel (DTX) is one of the most promising chemotherapeutic agents for a variety of solid tumors. However, the clinical efficacy of the marketed formulation, Taxotere®, is limited due to its poor aqueous solubility, side effects caused by the emulsifier, and low selective DTX distribution in vivo. Here a facile, well-defined, and easy-to-scale up DTX-loaded N-(tert-butoxycarbonyl)-L-phenylalanine end-capped methoxy-poly(ethylene glycol)-block-poly(D,L-lactide) (mPEG-b-PLA-Phe(Boc)) micelles (DTX-PMs) were prepared in an effort to

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Together with molecular dynamics simulations, the structures also revealed how FUT8 dimerization plays an important role in defining the acceptor substrate-binding site. Collectively, this information significantly builds on our understanding of the core fucosylation process. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.Inhibition of BET protein bromodomains BD1 and BD2 produces unique phenotypes in disease models. ©2020 American Association for Cancer Research.Patients with HPV16

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Also, the optical results revealed that CZ1 and CZ2 display λabs and λemi in the order of 410-430 nm and 530-560 nm, respectively, with a bandgap in the range of 2.5-2.6 eV. Finally, their quantum chemical simulations have provided an insight into the predictions of their structural, molecular, electronic and optical parameters. Conclusively, the study furnishes a deeper understanding of the intricacies involved in the structural modification of carbazole-based HTMs for achieving better performance.Experimental drought has been sh

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Sotagliflozin, a dual sodium-glucose co-transporter (SGLT)1/SGLT2 inhibitor, is currently approved in Europe as an adjunct to optimal insulin therapy in adults with type 1 diabetes (T1D) and a body mass index (BMI) ≥ 27 kg/m2 . In this post hoc analysis, efficacy at 24 weeks and safety at 52 weeks from pooled phase 3 clinical trials were evaluated in patients with baseline BMI ≥ 27 kg/m2 . Sotagliflozin 200 mg and 400 mg added to insulin reduced glycated haemoglobin level and increased time in range assessed by continuous glucose monito

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Specific pharmacokinetic studies are needed. © 2020 Blackwell Verlag GmbH.Angiogenic-, mitochondrial- and related transcriptional proteins were assessed in human skeletal muscle and isolated vascular cells during the early phase of endurance training. Thigh muscle biopsies were obtained in healthy young subjects, after one acute bout (n=9) and after 3, 5, 7 and 14 days (n=9) of cycle ergometer training. Whole muscle homogenates were analyzed for angiogenic, mitochondrial, and regulatory mRNA and protein levels. Angiogenic proteins w