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039). Regarding cisplatin, scores were lower in BRCA mutants and BRCAness tumors than their counterparts. A negative correlation was found between BRCA1-like scores and cisplatin sensitivity (r = -0.407; P = 0.013). No differences were found for epirubicin. BRCA1 gene knockdown increased the cisplatin sensitivity of Michigan Cancer Foundation-7 cells. CONCLUSIONS BRCA1-like scores were associated with cisplatin sensitivity and docetaxel resistance. BRCA1-like score is hence a promising indicator for estimating drug sensitivities in TNBC.

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These data suggest that, as demonstrated previously for specific neuronal populations, ALK1 expression in blood vessels is also vulnerable to the AD pathophysiologic process, perhaps related to CAA. However, cortical arterioles may remain responsive to the ALK1 ligands, such as BMP9 and BMP10 in early and moderate AD. To review community-level consumption of antibiotics in rural Vietnam, according to the WHO Access, Watch, Reserve (AWaRe) classification of 2019, and identify factors associated with the choice of these antibiotics. I

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The Ultimate Guide to Baby Cots Sale: Finding the Perfect Sleep Solution for Your Child When it pertains to getting ready for a brand-new arrival, one of the most important choices parents face is selecting the right baby cot. The baby cot is more than just a furniture piece; it is an important investment that guarantees the safety, convenience, and wellness of a newborn. With different designs, produ

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To describe a new international dataset for pathology reporting of colorectal cancer surgical specimens, produced under the auspices of the International Collaboration on Cancer Reporting (ICCR). Quality of pathology reporting and mutual understanding between colorectal surgeon, pathologist and oncologist are vital to patient management. Some pathology parameters are prone to variable interpretation, resulting in differing positions adopted by existing national datasets. The ICCR, a global alliance of major pathology institutions

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In the dynamic world of online marketing, discovering the appropriate tools to enhance your agency's performance is key. Introducing GoHighLevel, a comprehensive platform developed to streamline your marketing strategies and improve your client services. With its Gohighlevel no-cost trial, you can try out a comprehensive suite of features that encompass CRM features to marketing automation, each designed for agencies. This offering allows you to get a feel of the GoHighLe

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This pilot study provides preliminary evidence that an SBI utilizing AAMT can reduce depressive symptoms. Future studies should ****te these findings using larger samples and disentangle possible mechanisms of change. DRKS-ID DRKS00021613 (retrospectively registered). DRKS-ID DRKS00021613 (retrospectively registered). Transcranial direct current stimulation (tDCS) of the cerebellum dynamically modulates cerebello-thalamo-cortical excitability in a polarity-specific manner during motor, visuo- motor and cognitive task

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bias and affect the quality of care that patients subsequently receive. These findings suggest that increased physician awareness when writing and reading medical records is needed to prevent the perpetuation of negative bias in medical care. This qualitative study found that physicians express negative and positive attitudes toward patients when documenting in the medical record. Although often not explicit, this language could potentially transmit bias and affect the quality of care that patients subsequently receive. These

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Heading time is a key trait in cereals affecting the maturation period for optimal grain filling before harvest. Here, we aimed to understand the factors controlling heading time in barley (Hordeum vulgare). We characterized a set of 274 barley accessions collected worldwide by planting them for 20 seasons under different environmental conditions at the same location in Kurashiki, Japan. We examined interactions among accessions, known genetic factors, and an environmental factor to determine the factors controlling heading response. Local

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Living Room Furniture Sale: The Ultimate Guide to Finding the Perfect Pieces A living room acts as the heart of a home-- an area where friends and family gather, where stories are shared, and where life takes place. Subsequently, selecting the right furniture for this location is essential, given its impact on both functionality and looks. To help homeowners create the ideal living room environment, furniture sales often feature a v