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In vivo therapeutic evaluations suggest that MTX@HSP-PEG-NPs significantly alleviate RA with a high therapeutic index and relatively low adverse systemic toxicities in comparison with free MTX at the same dose. Our study shows that HSP-PEG-NPs could serve as multifunctional vehicles to deliver radioisotopes for in vivo imaging, and MTX for RA treatment, highlighting the innovative development of the nanoparticle-based RA treatment strategy for clinical applications.The degradation of biochemical reagents on the timescale of weeks

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We aimed to assess whether the safety outcomes exerted by sodium-glucose cotransporter 2 (SGLT2) inhibitors were associated with different renal function at baseline. We searched randomized controlled trials comparing SGLT2 inhibitors with placebo in participants simultaneously involving the entire range of estimated glomerular filtration rate (eGFR) levels at baseline in one study. According to eGFR, we divided the population into two subgroups with eGFR 60ml/min/1.73m and eGFR≥60ml/min/1.73m . Data from the CANVAS pro

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Preoperative templating for total hip arthroplasty (THA) on digital radiography can be achieved using templating software or hybrid methods (acetate templates overlaid on digital images). No studies have examined templating with a mobile phone. We evaluated the accuracy and reproducibility of a new digital templating method using the picture archiving and communication system (PACS) and iPhone, compared with the hybrid method for cementless THA. A total of 113 hip radiographs were retrospectively templated by three observers. For the dig

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