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BACKGROUND Clinical trials are expensive and often require funding from the pharmaceutical industry (PI). We aimed to compare studies funded by the PI with studies funded by other sources in terms of costs, reported results and strength of evidence. METHODS We searched PubMed for clinical trial reports on metastatic NSCLC published between 2012 and 2017. We divided all studies into two groups studies funded by the PI or by other sources. The primary endpoint was to compare the evidence strength of each group. Secondary endpoints were

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In the modern digital environment, businesses of all sizes are dealing with the question of whether to hire an SEO agency. With numerous choices asserting they are the top, especially in vibrant markets like Houston, it can be overwhelming to choose. The rise of online contenders has made SEO an integral part of effective marketing strategies, but is hiring an agency the right choice for you? Grasping your particular objectives and requirements is key. Whether you’re a new startup seeking to build an online identity or a bigger firm ai

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ult than other anatomy such as kidney tumors. Less experienced participants appear to under-segment models and underestimate the size of prostate tumors. Segmentation of prostate cancer is highly variable even among radiologists, and 3D modeling for clinical use must be performed with caution. Further work to develop a methodology to maximize segmentation accuracy is needed. The survival benefits of perioperative chemoradiotherapy (PCRT) and perioperative chemotherapy (PCT) for resectable gastric cancer (GC) patients remain unclear.This study aimed to compa

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EFFECTS recruited 1500 patients at 35 centres in Sweden between 20 October 2014 and 28 June 2019. We plan to unblind the data in January 2020 and report the primary outcome in May 2020. CONCLUSION EFFECTS will provide data on the safety and efficacy of 6 months of treatment with fluoxetine after stroke in a Swedish health system setting. The data from EFFECTS will also contribute to an individual patient data meta-analysis. TRIAL REGISTRATION EudraCT 2011-006130-16. Registered on 8 August 2014. ISRCTN, ISRCTN13020412. Registered on 19 Decem

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Despite aggressive treatment with steroids, tocilizumab and other supportive measures, the patient died of cardiac arrest. Our case highlights that acute stroke could manifest as an isolated dysarthria, which is an indicator of increased severity and high mortality with COVID-19 infection. Public awareness about the stroke symptom awareness should be emphasized.Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by platelet count less than 100×109/L and an increased risk of bleeding. The risk of bleeding increases in p

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On top of that, the loss of the heterodimer can be effectively suppressed to a level well below that of a pure metal nanoparticle, which further benefits the forward scattering efficiency. The flexibility in designing the dimer geometry and choosing metal-dielectric material combinations enables efficient unidirectional forward scattering in a broadband spectrum (UV to visible) with an intermediate gap distance (10-20 nm), greatly expanding the application scope. The proposed hybrid dimer could serve as a powerful and ve

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