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Field-effect transistor (FET) biosensors based on low-dimensional materials are capable of highly sensitive and specific label-free detection of various analytes. In this work, a FET biosensor based on graphene decorated with gold nanoparticles (Au NPs) was fabricated for lactose detection in a liquid-gate measurement configuration. This graphene device is functionalized with a carbohydrate recognition domain (CRD) of the human galectin-3 (hGal-3) protein to detect the presence of lactose from the donor effect of lectin - glycan affinity

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Sertraline and fluoxetine are the two most commonly used selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression. Accumulating evidence has revealed that SSRIs can reduce the risk of hepatocellular carcinoma (HCC), but their therapeutic effects in HCC have not yet been elucidated. Previous studies have reported that sertraline and fluoxetine can suppress the growth of gastric carcinoma, melanoma and nonsmall cell lung cancers by inhibiting the mammalian target rapamycin (mTOR) activity. In this study, we found th

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24, 95%CI 0.10 to 0.63; p = 0.003) and whole blood selenium (RR = 0.41, 95%CI 0.26 to 0.65; p = 0.004) studies, rather than prospective cohort (RR = 0.88, 95%CI 0.52 to 1.48; p = 0.62) and serum/plasma selenium (RR = 0.55, 95%CI 0.22 to 1.40; p = 0.21) studies. Moreover, the overall combined WMD showed that the circulating selenium level in stroke was lower than that in control subjects (WMD = -0.16, 95%CI -0.29 to -0.03; p = 0.017), which was further confirmed in whole blood selenium (WMD = -0.26, 95%CI -0.44 to -0.08; p = 0.005), r

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Ago upregulated estrogen receptor (ER α and β) mRNA expression in the hippocampus of OVX rats and elevated serum estradiol levels. Co-administration of E2 with Ago synergistically decreased NF-kB P65 expression and pro-inflammatory cytokines, and increased BDNF levels. Conclusion E2 augmented the neuroprotective effect of Ago in OVX rats via its anti-inflammatory and neurotrophic effects. The combined treatment of E2 and Ago should be further investigated as a treatment of choice for depression, anxiety, and sleep disturbances associat

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Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) is an exceptionally rare autosomal dominant condition caused by a germline heterozygous mutation of the fumarate hydratase gene. It manifests as multiple piloleiomyomas, associated with numerous, early-onset uterine leiomyomas in female patients, as well as a highly increased risk of renal cell carcinoma (RCC), most often type 2 papillary RCC. HLRCC has been described in association with adrenal cortical hyperplasia, pheochromocytoma, adrenal cortical carcinoma, and other s

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Ethnic identity is an important protective factor for various ethnic groups and developmental periods. Although existing measures assessing ethnic identity are well known, less is known about the measurement invariance of the Multigroup Ethnic Identity Measure (MEIM) across adolescent ethnic groups. The present study evaluates the factor structure of MEIM (Roberts et al., 1999) and tests the measurement invariance across early and middle adolescence and ethnic background (N=494. Data from an ethnic minority sample of youth (5

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Comprehensive Guide to Composite Door Repairs: An In-Depth Look Composite doors have actually gotten immense popularity in current years due to their excellent sturdiness, visual appeal, and energy performance. Unlike traditional wood doors, composite doors are made from a mix of products, typically integrating wood, PVC, and glass-reinforced plastic. While they use many advantages, composite doors are not unsusceptible to use and tear, weather challenges, and unintentional damage. Understanding how to repair them is vital for house owners looking to preserve

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CONCLUSIONS This study found that bilateral hematoma, hyperdense hematoma and anticoagulant drug use were independently associated with CSDH recurrence. Clinical presentation of headache was the strongest predictor of postoperative AIH, and intraoperative irrigation decreased the incidence of postoperative AIH.BACKGROUND Previous studies have indicated that the JAK/STAT signaling pathway is involved in modulating arterial adventitia inflammation response. In this study, we designed experiments to further investigate the effect of JA

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The impact of drug-drug interactions (DDI) between ritonavir-boosted lopinavir (LPV-r) to treat patients with coronavirus disease 2019 (COVID-19) and commonly used drugs in clinical practice is not well-known. Thus, we evaluated the rate and severity of DDI between LPV-r for COVID-19 treatment and concomitant medications. This was a cross-sectional study including all individuals diagnosed of SARS-CoV-2 infection treated with LPV-r and attended at a single center in Southern Spain (March 1st to April 30th, 202. The frequency [95% conf

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Navigating the Road to Freedom: Understanding the Diverse Experiences of Obtaining a Driving License The simple driving license. It's more than just a piece of laminated plastic; it's a secret that unlocks a world of independence and chance. For lots of, obtaining a driving license is a significant rite of passage, ma